Research

Research

Research in NDM

The department supports investigator-led research through a series of well-founded laboratories. This research covers every aspect of biological science related to medicine: from the bench to the bedside, from blue sky to full clinical trials, from technology development to spin-out. It covers many fields and many clinical disciplines.

Researchers

The department supports this research in an environment designed to foster the long-term career development of fellows and research staff.

All of the above is made possible through the generosity and long-term support of our sponsors and funders.

Research Highlights

Intragenic transcriptional interference regulates the human immune ligand MICA.

Intragenic transcriptional interference regulates the human immune ligand MICA.

Posted 23/08/2018

Disease processes can switch genes on or off in a cell and this can alter the progress of the disease. In studying the control of immune genes, Chris O’Callaghan and colleagues have discovered a new form of regulation in human genes—interacting control elements within an individual gene can flip the switch on the gene in the opposite direction to that expected.

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

Posted 03/08/2018
Ross Chapman and WTCHG colleagues have published their research in Nature which describes the discovery of the Shieldin complex, a single-stranded DNA-binding repair complex that is essential for context-dependent DNA repair events in the immune system and cancer.

Research Highlights archives