Research

Research

Research in NDM

The department supports investigator-led research through a series of well-founded laboratories. This research covers every aspect of biological science related to medicine: from the bench to the bedside, from blue sky to full clinical trials, from technology development to spin-out. It covers many fields and many clinical disciplines.

Researchers

The department supports this research in an environment designed to foster the long-term career development of fellows and research staff.

All of the above is made possible through the generosity and long-term support of our sponsors and funders.

Research Highlights

Study reveals why cancer cells spread within the body

Study reveals why cancer cells spread within the body

Posted 17/01/2017

A new study led by Professor Colin Goding has identified an ancient cellular response, conserved through eons of evolution, that underlies the spread of the aggressive skin cancer melanoma. The study published in the current issue of the journal Genes & Development, illuminates the crucial role that punishing conditions within the tumour play in moulding a subset of tumour cells into an invasive state. The findings also help explain why some melanoma patients respond relatively poorly to both a key targeted therapy and an immunotherapy known as PD-1 blockade and suggest novel strategies for treating this form of skin cancer.

Some lung cancers may be susceptible to existing therapy:

Some lung cancers may be susceptible to existing therapy:

Posted 06/12/2016
Professor Sebastian Nijman has found that a subset of lung tumors known to be relatively resistant to therapy is susceptible to a class of recently approved anti-cancer drugs. The findings, published in Nature Communications, suggest a new and more personalized therapy for non-small cell lung cancers characterised by mutations to a gene known as ATM.

Research Highlights archives