The department supports investigator-led research through a series of well-founded laboratories. This research covers every aspect of biological science related to medicine: from the bench to the bedside, from blue sky to full clinical trials, from technology development to spin-out. It covers many fields and many clinical disciplines.
The department supports this research in an environment designed to foster the long-term career development of fellows and research staff.
All of the above is made possible through the generosity and long-term support of our sponsors and funders.
Pneumothorax is a common condition which can affect anyone where air leaks from the lung and causes lung collapse. Researchers from the Clinical Trials Support Unit and Oxford Respiratory Trials Unit have conducted the world’s largest ever analysis of pneumothorax (over 170,000 cases) using hospital records, and demonstrated that this condition is increasing. The reasons for this are not clear, but provide important data on trends in this disease, and highlight the need for further research in to treatment and prevention
Disease processes can switch genes on or off in a cell and this can alter the progress of the disease. In studying the control of immune genes, Chris O’Callaghan and colleagues have discovered a new form of regulation in human genes—interacting control elements within an individual gene can flip the switch on the gene in the opposite direction to that expected.