The department supports investigator-led research through a series of well-founded laboratories. This research covers every aspect of biological science related to medicine: from the bench to the bedside, from blue sky to full clinical trials, from technology development to spin-out. It covers many fields and many clinical disciplines.
The department supports this research in an environment designed to foster the long-term career development of fellows and research staff.
All of the above is made possible through the generosity and long-term support of our sponsors and funders.
Hepatitis B virus (HBV) infects 290 million people worldwide. Oxford Nanopore Technology sequencing platforms provide potential for sequencing the whole HBV genome in a single read, facilitating improved insights into virus epidemiology, diversity, and pathogenesis. Dr Anna McNaughton and fellow researchers from the Translational Gastroenterology Unit have developed laboratory and bioinformatic methods enabling accurate HBV sequencing using the Nanopore platform
Chikungunya virus (CHIKV) has caused explosive outbreaks in more than 60 countries. Infection can cause a long-term, debilitating disease characterised by joint inflammation and chronic arthritis lasting several years. No licensed vaccine is yet available, but the team lead by Prof Reyes-Sandoval has developed a Chikungunya vaccine using the adenovirus ChAdOx1 expressing Virus-Like Particles that elicit immune responses able to produce high antibody titres able to neutralise the virus.