Tomáš Hanke
BSc MSc PhD
Professor of Vaccine Immunology
- Distinguished Professor, Kumamoto University, Japan (2015-2023)
HIV Vaccine Development
Targeting HIV Where It Hurts
Professor Hanke has dedicated his entire professional career to fighting the HIV-1/AIDS pandemic. His work has focused on the iterative improvement of T-cell vaccine design, encompassing both immunogens and delivery platforms, guided partly by preclinical studies but primarily driven by human clinical data. He coordinates and supports a global programme of experimental medicine trials evaluating his candidate T-cell vaccines, both as standalone interventions and in combination with other cutting-edge HIV cure strategies. These studies span five continents and are conducted in partnership with international networks, while simultaneously strengthening African research capacity and clinical trial infrastructure.
In addition to securing numerous smaller awards, Professor Hanke has led two UK Medical Research Council (MRC) Programme Grants and coordinated three successive consortia funded by the European & Developing Countries Clinical Trials Partnership (EDCTP). He has served on the trial leadership teams for the Horizon 2020 European AIDS Vaccine Initiative 2020, MRC-funded Translational Medicine awards (HIVA, PEACHI, RIVER and AbVax), the Advancing Clinical Therapeutics Globally (ACTG) network, the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network, and the U.S. Military HIV Research Program in partnership with the Henry M. Jackson Foundation for the Advancement of Military Medicine. Between 2015 and 2023, he was seconded to the University of Kumamoto, Japan, as a Distinguished Professor. In 2023, he and his collaborators at IrsiCaixa were awarded the European Hector Research Award for HIV Therapy in recognition of their contributions to the field.
Recent publications
MVA.tHIVconsvX vaccination-evoked T cell expansion inversely associates with age in people with HIV-1 on antiretroviral therapy.
Journal article
Gay CL. et al, (2026), The Journal of clinical investigation
PD-1 blockade enhances functional vaccine-induced HIV-1 CD8+ T-cell responses in PWH receiving early ART
Journal article
Marin M. et al, (2026), eBioMedicine, 123, 106070 - 106070
Safety and broad immunogenicity of HIVconsvX conserved mosaic candidate T-cell vaccines vectored by ChAdOx1 and MVA in HIV-CORE 006: a double-blind, randomised, placebo-controlled phase 1 trial in healthy adults living without HIV-1 in eastern and southern Africa.
Journal article
Chanda C. et al, (2025), The Lancet. Microbe, 6
Safety and immunogenicity of the ChAdOx1-MVA-vectored conserved mosaic HIVconsvX candidate T-cell vaccines in HIV-CORE 005.2, an open-label, dose-escalation, first-in-human, phase 1 trial in adults living without HIV-1 in the UK.
Journal article
Borthwick N. et al, (2025), The Lancet. Microbe, 6
Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine
Journal article
Bruton J. and Hanke T., (2025), Vaccines, 13, 72 - 72