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Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China.

Tian S., Wu X., Liu L., Li A., Li X., Pei H., Wang Y., Dance DAB., Chen H., Xia Q.

In a clinical isolate of Burkholderia pseudomallei from Hainan, the association between the emergence of ceftazidime resistance and a novel PenA P174L allele was identified for the first time, providing an understanding of one mechanism by which ceftazidime resistance arises in B. pseudomallei.

More information Original publication

DOI

10.1016/j.drup.2024.101121

Type

Journal article

Publication Date

2024-09-01T00:00:00+00:00

Volume

76

Addresses

N, H, C, , K, e, y, , L, a, b, o, r, a, t, o, r, y, , o, f, , T, r, o, p, i, c, a, l, , D, i, s, e, a, s, e, , C, o, n, t, r, o, l, ,, , S, c, h, o, o, l, , o, f, , T, r, o, p, i, c, a, l, , M, e, d, i, c, i, n, e, , a, n, d, , T, h, e, , S, e, c, o, n, d, , A, f, f, i, l, i, a, t, e, d, , H, o, s, p, i, t, a, l, ,, , H, a, i, n, a, n, , M, e, d, i, c, a, l, , U, n, i, v, e, r, s, i, t, y, ,, , H, a, i, k, o, u, ,, , H, a, i, n, a, n, ,, , C, h, i, n, a, .

Keywords

Humans, Burkholderia pseudomallei, Melioidosis, Ceftazidime, Bacterial Proteins, Anti-Bacterial Agents, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Point Mutation, Alleles, China