Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset.
Tan R., Chandna A., Colbourn T., Hooli S., King C., Lufesi N., McCollum ED., Mwansambo C., Mathew JL., Cutland CL., Madhi SA., Nunes M., Basnet S., Strand TA., O'Grady K-AF., Gessner B., Addo-Yobo E., Chisaka N., Hibberd P., Jeena PM., Lozano JM., MaLeod WB., Patel A., Thea DM., Nguyen NTV., Lucero M., Akram Uz Zaman SM., Bhatnagar S., Wadhwa N., Lodha R., Aneja S., Santosham M., Awasthi S., Bavdekar A., Chou M., Nymadawa P., Pape JW., Paranhos-Baccala G., Picot VS., Rakoto-Andrianarivelo M., Rouzier V., Russomando G., Sylla M., Vanhems P., Wang J., Libster R., Clara AW., Beynon F., Levine G., Rees CA., Neuman MI., Qazi S., Nisar YB., World Health Organization PREPARE study group .
BackgroundHypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to develop and validate a simple risk score comprising commonly evaluated clinical features to predict hypoxaemia in 2-59-month-old children with pneumonia.MethodsData from seven studies conducted in five countries from the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) dataset were included. Readily available clinical features and demographic variables were used to develop a multivariable logistic regression model to predict hypoxemia (oxygen saturation <90%) at presentation to care. The adjusted log coefficients were transformed to derive the PREPARE hypoxemia risk score and its diagnostic value was assessed in a held-out, temporal validation dataset. The model and risk score were analysed by evaluating the area under the receiver operating characteristic curve (AUC), sensitivity and specificity.ResultsWe included 14 509 children in the analysis; 9.8% (n=2515) were hypoxemic at presentation. The multivariable regression model to predict hypoxemia included age, sex, respiratory distress (nasal flaring, grunting and/or head nodding), lower chest indrawing, respiratory rate, body temperature and weight-for-age z-score. The model showed fair discrimination (AUC 0.70, 95% CI 0.67 to 0.73) and calibration in the validation dataset. The simplified PREPARE hypoxaemia risk score includes five variables: age, respiratory distress, lower chest indrawing, respiratory rate and weight-for-age z-score.ConclusionThe PREPARE hypoxemia risk score, comprising five easily available characteristics, has the potential to be used to identify hypoxemia in children with pneumonia with a fair degree of certainty for use in health facilities without pulse oximetry. Its implementation would require careful consideration to limit the burden of inappropriate referrals on patients and the health system. Further external validation in community settings in low- and middle-income countries is required.