BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine.
Reinke S., Ulaszewska M., Su Q., Sims L., Guyon R., Truby A., Raissar G., Bezbradica JS., Fergusson JR., Milicic A.
BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8+ T cell-dependent protection. Our findings suggest co-immunisation with BCG and adenoviral vector as a promising strategy to combat both TB and malaria in double-endemic regions.