NetPath: a public resource of curated signal transduction pathways
Kandasamy K., Mohan SS., Raju R., Keerthikumar S., Kumar GSS., Venugopal AK., Telikicherla D., Navarro JD., Mathivanan S., Pecquet C., Gollapudi SK., Tattikota SG., Mohan S., Padhukasahasram H., Subbannayya Y., Goel R., Jacob HKC., Zhong J., Sekhar R., Nanjappa V., Balakrishnan L., Subbaiah R., Ramachandra YL., Rahiman BA., Prasad TSK., Lin J-X., Houtman JCD., Desiderio S., Renauld J-C., Constantinescu SN., Ohara O., Hirano T., Kubo M., Singh S., Khatri P., Draghici S., Bader GD., Sander C., Leonard WJ., Pandey A.
AbstractWe have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.