Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi
Kosaisavee V., Suwanarusk R., Chua ACY., Kyle DE., Malleret B., Zhang R., Imwong M., Imerbsin R., Ubalee R., Sámano-Sánchez H., Yeung BKS., Ong JJY., Lombardini E., Nosten F., Tan KSW., Bifani P., Snounou G., Rénia L., Russell B.
Key PointsZoonotic P cynomolgi switches red cell tropism for reticulocytes expressing Trf1 (CD71+) and DARC (CD234+). In the human host, P cynomolgi displays an almost identical rheopathobiology to P vivax.