Research groups
Yi-Ling Chen
DPhil
Career Development Fellow
I have a particular interest in lipid-reactive T cells and their roles in immune regulation, with the goal of advancing our understanding of how commensal and pathogenic responses contribute to tissue homeostasis and microbial defense at both cellular and molecular levels.
Using high-dimensional proteotranscriptomics, T cell clonality analysis, and human immune organoid approaches, my research seeks to uncover fundamental molecular mechanisms and discover new therapeutic candidates for immune intervention. These efforts are directed toward translational applications that could inform future treatments for inflammatory and infectious diseases.
Recent publications
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Journal article
Hamid MHBA. et al, (2024), Nature Immunology, 25, 834 - 846
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Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19
Preprint
Luo J. et al, (2024)
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CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms.
Journal article
Huang S. et al, (2023), Cell, 186, 4583 - 4596.e13
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Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Journal article
Chen Y-L. et al, (2023), Science immunology, 8
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CD1a promotes systemic manifestations of skin inflammation.
Journal article
Hardman CS. et al, (2022), Nature communications, 13