Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo
Lee SY., Brem J., Pettinati I., Claridge TDW., Gileadi O., Schofield CJ., McHugh PJ.
The human metallo-β-lactamase fold DNA repair enzymes SNM1A and SNM1B can be inhibited by cephalosporin-family molecules, revealing a potential new strategy to chemosensitive tumours, as well as a novel evolutionary link.