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Central Nervous System Involvement by Novel Clade 2.3.2.1e H5N1 Avian Influenza Virus in a Pediatric Patient.

Nguyen PNT., Hung NT., Minh NNQ., Hong NTT., Huong NTT., Hiep CM., Nhan LNT., Dinh TV., Quy DT., Thuc TT., Nhut TM., Ny NTH., Nguyet LA., Nhu LNT., Han DDK., Truc THC., Uyen LTT., Ngoc NM., Thao TNP., Tam TTT., Mak ST-M., Siegers JY., Maurer-Stroh S., Dung NT., Karlsson EA., Thwaites G., Tan CW., Chau NVV., Tan LV., SEACOVARIANTS and H5N1 Consortia .

Novel clade 2.3.2.1e A(H5N1) virus was detected in cerebrospinal fluid but not in respiratory, rectal swab, or blood samples of an 8-year-old boy presenting with meningoencephalitis without respiratory symptoms. Cerebrospinal fluid A(H5N1) hemagglutinin-specific antibody levels were higher than those of sera. Clinicians should be aware of emerging clade 2.3.2.1e A(H5N1)-associated meningoencephalitis.

More information Original publication

DOI

10.1093/ofid/ofag283

Type

Journal article

Publication Date

2026-05-01T00:00:00+00:00

Volume

13

Addresses

U, n, i, v, e, r, s, i, t, y, , o, f, , M, e, d, i, c, i, n, e, , a, n, d, , P, h, a, r, m, a, c, y, , a, t, , H, o, , C, h, i, , M, i, n, h, , C, i, t, y, ,, , H, o, , C, h, i, , M, i, n, h, , C, i, t, y, ,, , V, i, e, t, n, a, m, .

Keywords

SEACOVARIANTS and H5N1 Consortia