ACTIVATION OF CYTOTOXIC LYMPHOCYTES IN PATIENTS WITH SCRUB TYPHUS
DE FOST M., CHIERAKUL W., PIMDA K., DONDORP AM., WHITE NJ., VAN DER POLL TOM.
Thai patients with scrub typhus caused by the intracellular pathogen Orientia tsutsugamushi displayed elevated plasma concentrations of granzymes A and B, interferon-γ (IFN)-γ–inducible protein 10, and monokine induced by IFN-γ. These data suggest that activation of cytotoxic lymphocytes is part of the early host response to scrub typhus.