CD45 is required for type I IFN production by dendritic cells
Montoya M., Dawes R., Reid D., Lee LN., Piercy J., Borrow P., Tchilian EZ., Beverley PCL.
AbstractCD45 is a leukocyte tyrosine phosphatase, essential for normal immune responses. We have studied the function of splenic dendritic cells of CD45+/+, CD45–/–, CD45RABC and CD45RO transgenic mice. We show that there are increased numbers of plasmacytoid dendritic cells in CD45–/– mice. DC of all mice are capable of responding to lymphocytic choriomeningitis virus (LCMV) infection by up‐regulation of MHC and costimulatory molecules. DC of CD45–/– mice have an impaired capacity to produce type I interferons in response to LCMV infection in vivo. These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes.