Microevolution of Burkholderia pseudomallei during an Acute Infection
Limmathurotsakul D., Holden MTG., Coupland P., Price EP., Chantratita N., Wuthiekanun V., Amornchai P., Parkhill J., Peacock SJ.
ABSTRACT We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.