Differential and limited expression of mutant alleles in multiple myeloma
Rashid NU., Sperling AS., Bolli N., Wedge DC., Van Loo P., Tai Y-T., Shammas MA., Fulciniti M., Samur MK., Richardson PG., Magrangeas F., Minvielle S., Futreal PA., Anderson KC., Avet-Loiseau H., Campbell PJ., Parmigiani G., Munshi NC.
Key Points The majority of mutations are found in genes that have low or no detectable biological expression. Mutated genes often show differential allelic expression in multiple myeloma patient samples.