Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety
Sansook S., Ocasio CA., Day IJ., Tizzard GJ., Coles SJ., Fedorov O., Bennett JM., Elkins JM., Spencer J.
A series of 3-methylidene-1 H -indol-2(3 H )-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF 5 -substituted oxindoles with a range of aldehydes.