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Malaria: What's New in the Management of Malaria?

Plewes K., Leopold SJ., Kingston HWF., Dondorp AM.

The global burden of malaria remains high, with 216 million cases causing 445,000 deaths in 2016 despite first-line treatment with artemisinin-based combination therapy. Decreasing transmission in Africa shifts the risk for severe malaria to older age groups as premunition wanes. Prompt diagnosis and treatment with intravenous artesunate in addition to appropriate supportive management are critical to reduce deaths from severe malaria. Effective individual management is challenging in settings with limited resources for higher-level care. Adjunctive therapies targeting the underlying pathophysiological pathways have the potential to reduce mortality. Resistance to artemisinin derivatives and their partner drugs threaten malaria management and control.

More information Original publication

DOI

10.1016/j.idc.2018.10.002

Type

Journal article

Publication Date

2019-03-01T00:00:00+00:00

Volume

33

Pages

39 - 60

Total pages

21

Addresses

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Keywords

Humans, Plasmodium, Malaria, Antimalarials, Drug Therapy, Combination, Drug Resistance, Disease Management