Single Cell Genomics Computational Biologist/Statistician (Human Immune Discovery Initiative)

Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford

Applications to be received by 12pm on Monday 18th of November 2019

Grade 8: £41,526 - £49,553 p.a.

We have an exciting opportunity for an experienced computational biologist/statistician to join the Genomics Platform of the University of Oxford Human Immune Discovery Initiative (HIDI) to analyse data generated by single-cell and spatial transcriptomics next-generation sequencing technologies. This initiative aims to investigate the role of immune cell types and activation states in health and disease, upon treatment, and in relation to genetic and environmental factors to help provide translational insights. This role provides a unique opportunity to lead the data analysis for rewarding research that is making a fundamental impact on human health.


You will be part of Calli Dendrou’s and Rory Bowden’s research groups at the Wellcome Centre for Human Genetics and will work collaboratively with clinicians and scientists in HIDI and in the Human Cell Atlas initiative to develop a streamlined platform for single-cell and spatial transcriptomics data analysis.


You should hold, or be close to completion of a PhD (or equivalent) in computational biology, statistics, bioinformatics or other related computational subject. Prior experience working with single-cell RNA-Seq and other relevant next generation sequencing data sets (preferably derived from human immune cells) is essential. Proficiency with a high-level programming language, appropriate scripting languages and also with statistical data analysis tools such as R or Python is required. A strong interest in working with medical and biological researchers towards a common goal is desirable. You should thrive on scientific challenges associated with analysing complex biological data sets, be keen to test and develop new analytical tools and methods, and be capable of learning and working independently. You should have good code and data management skills to enable reproducible research, and be capable of simultaneously working on different projects and deadlines. You will be expected to document all work thoroughly, to provide manuscript-level reporting of final analyses and results, and to contribute to manuscript writing for publication as a first author and co-author, and to grant writing.


The position is fixed-term for 2 years in the first instance and is funded by the National Institute for Health Research and the Wellcome Centre for Human Genetics.


An appointment at Grade 7 (£32,817 - £39,152 p.a.) may be considered for a less experienced candidate with suitable adjustment of the responsibilities.


Please quote reference 143522 on all correspondence.


Only applications received before 12.00 midday on Monday 18 November 2019 can be considered.

Contact: Farha Hoque (01865 287507)