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Professor Chas Bountra is interested in identifying and validating target proteins for drug discovery. Various technologies and strategies have allowed him to progress promising clinical candidates into Phase I, II, III studies, and to market. These new drugs offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders.

You just have to step into your local chemist to see how far medicine has come over the past 100 years. Life-changing drugs, which were once unthinkable – like antibiotics, insulin and the contraceptive pill - are now commonplace.

But there's still so much we don't know about the medicines we take.

Drug companies are struggling to keep up with the rising demand for new medicines because of the competitive, timely and costly nature of the drug discovery pipeline. In order to deliver new medicines to the people who need them the most, researchers and drug companies need to work together to speed up the process of drug discovery.

By opening up access to newly discovered protein structures and drug targets, Oxford researchers are doing just that.

Revolutionary Biology

NDM celebrates the International Year of Crystallography. Our documentary series Revolutionary Biology explains how the field of structural biology has developed over the past 100 years, Oxford's involvement in that development, and where we go from here!

Part 1: The building blocks of life

Part 2: The history of structural biology

Part 3: Advanced technology

Part 4: A new age of drug discovery

Translational Medicine

From Bench to Bedside

Ultimately, medical research must translate into improved treatments for patients. At the Nuffield Department of Medicine, our researchers collaborate to develop better health care, improved quality of life, and enhanced preventative measures for all patients. Our findings in the laboratory are translated into changes in clinical practice, from bench to bedside.