Professor Christiane Dolecek
Contact information
Christiane Dolecek
MD PHD FRCP
Professor of Global Health
- Senior Clinical Scientist
- Co-Director MICROBE group
- Co-Lead and Co-PI of the GRAM project Oxford
ANTIMICROBIAL RESISTANCE, ANTIMICROBIAL CONSUMPTION AND USE
Prof Christiane Dolecek is a senior clinical scientist and global health researcher. She has been undertaking research on infectious diseases for more than 25 years. Her work focusses on drug-resistant infections, and antibiotic use and consumption.
She is one of the founding members of the GRAM (Global Burden of Disease - Antimicrobial resistance) project, a collaboration between the University of Oxford and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. The aim of the GRAM project is to measure and map the global burden of disease attributable to bacterial antimicrobial resistance (AMR). During GRAM-1, Christiane led a small team at Tropical Medicine. In GRAM-2 Christiane serves as the co-director of the MICROBE group and co-lead and co-PI of the GRAM project Oxford.
She is involved and active in several international consortia, including STRATAA, ACT-South Asia, COVID-19 and AMR, and is the Oxford PI of the Code-ICI project. Christiane is committed to mentoring and capacity building.
Christiane has a strong interest in evidence-based medicine, including clinical trials and the evaluation of clinical outcomes in infectious diseases. She was previously based at the Oxford University Clinical Research Unit in Ho Chi Minh City, Vietnam, from 2001 till 2013. Together with a team of superb researchers, Christiane has been leading a series of enteric fever trials in Vietnam and Nepal with the aim to systematically access the current World Health Organization recommendations as well as new treatment options.
She has been an external adviser to the World Health Organization Global Antimicrobial Resistance and Use Surveillance System (WHO GLASS) and co-Chair of the Global Health Strategy Group on Antimicrobial Resistance, an interdisciplinary network of researchers working on AMR, part of the Oxford-Berlin partnership. She has co-authored more than 90 publications including contributions to the Lancet, Science, Nature Genetics, Lancet Infectious Diseases, PNAS, the PLOS journals and eLife.
Christiane obtained her medical degree from the University of Vienna and specialised in Immunology before moving her academic focus to clinical research in infectious diseases. She obtained her PhD from the London School of Hygiene and Tropical Medicine in 2011.
Collaborations
Key publications
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Global antibiotic consumption and usage in humans, 2000-18: a spatial modelling study.
Journal article
Browne AJ. et al, (2021), The Lancet. Planetary health, 5, e893 - e904
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Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Journal article
Murray CJL. et al, (2022), The Lancet, 399, 629 - 655
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Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study
Journal article
Browne AJ. et al, (2024), The Lancet Global Health, 12, e406 - e418
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Measuring and mapping the global burden of antimicrobial resistance
Journal article
Hay SI. et al, (2018), BMC Medicine, 16
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Drug-resistant bacterial infections: We need urgent action and investment that focus on the weakest link.
Journal article
Dolecek C. et al, (2022), PLoS biology, 20
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Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial
Journal article
Arjyal A. et al, (2011), The Lancet Infectious Diseases, 11, 445 - 454
Recent publications
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A novel framework for quantifying the clinical impact of substandard and falsified antimicrobials: application to typhoid fever.
Preprint
Cavany SM. et al, (2025)
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Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Journal article
Naghavi M. et al, (2024), The Lancet, 403, 2100 - 2132
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Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study
Journal article
Browne AJ. et al, (2024), The Lancet Global Health, 12, e406 - e418
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Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study.
Journal article
Ashton PM. et al, (2024), The Lancet. Microbe, 5, e226 - e234
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Mapping the incidence rate of typhoid fever in sub-Saharan Africa.
Journal article
Kim J-H. et al, (2024), PLoS neglected tropical diseases, 18
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The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis
Journal article
Sartorius B. et al, (2024), The Lancet Global Health, 12, e201 - e216