Richard Wheeler
The Wheeler Lab is primarily researching how the highly motile single cell eukaryotic parasites which cause leishmaniasis (Leishmania species) and sleeping sickness (African trypanosomes) control their swimming and how this contributes to progression through their life cycles.
Research in this group exploits high content automated analysis of large data sets from light and electron microscopy, supported by mathematical modelling, to analyse how flagellum structure and cell shape contribute to cell swimming behaviours, how the cell generates these precisely defined structures and why parasites adapt their swimming to the different host and vector environments they encounter through their life cycles.
Much of this work also speaks to general questions regarding cell motility and flagellum function, including how defects in flagella cause human genetic disease - ciliopathies.
Supporting this work, Richard Wheeler co-manages the TrypTag.org data set a project which has determined the sub-cellular localisation of every trypanosome protein. Protein localisation within the highly structured trypanosome cells is informative for function and is a major new cell biology and parasitology resource while also supporting research in his group.
Recent publications
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Small-molecule dissolution of stress granules by redox modulation benefits ALS models.
Journal article
Uechi H. et al, (2025), Nat Chem Biol
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Kharon Is Crucial for Trypanosoma cruzi Morphology but Does Not Impair In Vitro Infection
Journal article
Saenz-Garcia JL. et al, (2025), Pathogens, 14, 312 - 312
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Evolutionary adaptations of doublet microtubules in trypanosomatid parasites
Journal article
Doran MH. et al, (2025), Science, 387
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A high-throughput protein tagging toolkit that retains endogenous untranslated regions for studying gene regulation in kinetoplastids
Journal article
Carbajo CG. et al, (2025), Open Biology, 15
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Humanity's Last Exam
Preprint
Phan L. et al, (2025)