C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

Le Bihan Y-V., Lanigan RM., Atrash B., McLaughlin MG., Velupillai S., Malcolm AG., England KS., Ruda GF., Mok NY., Tumber A., Tomlin K., Saville H., Shehu E., McAndrew C., Carmichael L., Bennett JM., Jeganathan F., Eve P., Donovan A., Hayes A., Wood F., Raynaud FI., Fedorov O., Brennan PE., Burke R., van Montfort RLM., Rossanese OW., Blagg J., Bavetsias V.

DOI

10.1016/j.ejmech.2019.05.041

Type

Journal article

Journal

European Journal of Medicinal Chemistry

Publisher

Elsevier BV

Publication Date

09/2019

Volume

177

Pages

316 - 337

Permalink Original publication