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Increasing attention has been focused on the use of recombinant mammalian viruses as potential vaccines. Recombinant human adenoviruses are one of the more promising vaccine vectors because they can be easily constructed and because live adenovirus vaccines have been administered orally to large numbers of military recruits without adverse reactions. In order to examine the efficacy of human adenoviruses as vaccines we have studied the immunity induced by a recombinant adenovirus vector, AdgB2, which induces high level expression of herpes simplex virus (HSV) glycoprotein B (gB) in human and murine cells. Mice inoculated with AdgB2 produced antibodies specific for gB which neutralized HSV in the presence of complement. Although mice inoculated with AdgB2 showed no ill-effects after AdgB2 inoculation and we were unable to detect replication of human adenoviruses in mice, the mice were protected from a lethal challenge with HSV after a single inoculation with AdgB2.

Type

Journal article

Journal

Virology

Publication Date

03/1989

Volume

169

Pages

244 - 247

Keywords

Adenoviruses, Human, Animals, Antibodies, Viral, Complement System Proteins, Cross Reactions, Enzyme-Linked Immunosorbent Assay, Female, Genetic Vectors, Herpes Simplex, Humans, Mice, Mice, Inbred BALB C, Neutralization Tests, Precipitin Tests, Simplexvirus, Vaccines, Synthetic, Viral Envelope Proteins, Viral Vaccines