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Serum haptoglobin levels were measured by an enzyme-linked immunosorbent assay in Gambian children who participated in 3 malaria intervention trials with untreated or impregnated bed nets. In one study, in which a significant effect on clinical malaria was observed, the mean serum haptoglobin level was significantly higher in the intervention than in the control group. In the other 2 studies, in which no significant protection was observed, mean haptoglobin levels were similar in intervention and control groups. Measurement of serum haptoglobin may provide a useful indirect measure of the effectiveness of malaria control programmes.


Journal article


Trans R Soc Trop Med Hyg

Publication Date





14 - 16


Bedding and Linens, Child, Child, Preschool, Female, Gambia, Haptoglobins, Humans, Infant, Insect Control, Insecticides, Malaria, Male, Permethrin, Pyrethrins