Viruses in Vietnamese Patients Presenting with Community-Acquired Sepsis of Unknown Cause
Anh NT., Hong NTT., Nhu LNT., Thanh TT., Lau C-Y., Limmathurotsakul D., Deng X., Rahman M., Chau NVV., van Doorn HR., Thwaites G., Delwart E., Tan LV.
Community-acquired (CA) sepsis is a major public health problem worldwide, yet the etiology remains unknown for >50% of the patients. Here we applied metagenomic next-generation sequencing (mNGS) to characterize the human virome in 492 clinical samples (384 sera, 92 pooled nasal and throat swabs, 10 stools, and 6 cerebrospinal fluid samples) from 386 patients (213 adults and 173 children) presenting with CA sepsis who were recruited from 6 hospitals across Vietnam between 2013 and 2015.