Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To improve virological suppression and address the emerging threat of HIV drug resistance, many low-income and middle-income countries are moving away from non-nucleoside reverse transcriptase inhibitors (NNRTI) and transitioning to dolutegravir as part of a more affordable and standardised antiretroviral therapy (ART). Although this transition could decrease the effect of rising NNRTI resistance and yield improved ART outcomes, it also presents new challenges. First, current safety concerns for dolutegravir use in women of childbearing potential require alternative solutions. Second, pre-existing resistance to the co-administered nucleoside reverse transcriptase inhibitors might reduce effectiveness and durability of dolutegravir, particularly if there is scarce access to viral load tests to monitor treatment outcomes. Third, there is inadequate information on the genetic correlates of resistance to dolutegravir, particularly in patients infected with HIV-1 non-B subtypes. Finally, clinical management of patients with confirmed virological failure on a dolutegravir-based regimen can pose challenges because of uncertainty around whether dolutegravir resistance has actually developed and switching is needed, or whether only interventions to improve adherence without switching are sufficient. These considerations should be addressed to consolidate expected gains from widespread introduction of dolutegravir in low-income and middle-income countries.

Original publication

DOI

10.1016/s1473-3099(18)30710-2

Type

Journal article

Journal

The Lancet. Infectious Diseases

Publication Date

07/2019

Volume

19

Pages

e246 - e252

Addresses

Amsterdam Institute for Global Health and Development, Department of Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Joep Lange Institute, Amsterdam, Netherlands.

Keywords

Humans, HIV Infections, Heterocyclic Compounds, 3-Ring, HIV Integrase Inhibitors, Drug Resistance, Viral, Developing Countries, Female, Male