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In this issue of Molecular Cell, Sampath et al. show a lysine methylase exhibits substrate promiscuity and variability in degree of product methylation (Sampath et al., 2007). Two lysines are found to be automethylated in G9a, and one is H3K9-like and can establish a docking site for HP1 chromodomain.

Original publication

DOI

10.1016/j.molcel.2007.08.002

Type

Journal article

Journal

Molecular cell

Publication Date

08/2007

Volume

27

Pages

521 - 522

Addresses

Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908-0733, USA.

Keywords

Animals, Humans, Mice, Protein Methyltransferases, Histone-Lysine N-Methyltransferase, Lysine, Histones, Signal Transduction, Epigenesis, Genetic, Molecular Mimicry, Substrate Specificity, Methylation