The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement
Prats-Ejarque G., Arranz-Trullén J., Blanco JA., Pulido D., Nogués MV., Moussaoui M., Boix E.
<jats:p>We describe the first human RNase 6 crystal structure in complex with sulfate anions. Kinetic analysis, site-directed mutagenesis and molecular dynamics simulations identified novel substrate recognition and cleavage sites.</jats:p>