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After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.

Original publication

DOI

10.1038/ng2015

Type

Journal article

Journal

Nat Genet

Publication Date

05/2007

Volume

39

Pages

638 - 644

Keywords

African Americans, Chromosomes, Human, Pair 8, Ethnic Groups, European Continental Ancestry Group, Genetic Predisposition to Disease, Genetic Variation, Genomics, Genotype, Haplotypes, Humans, Male, Odds Ratio, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors, United States