Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
Zink F., Stacey SN., Norddahl GL., Frigge ML., Magnusson OT., Jonsdottir I., Thorgeirsson TE., Sigurdsson A., Gudjonsson SA., Gudmundsson J., Jonasson JG., Tryggvadottir L., Jonsson T., Helgason A., Gylfason A., Sulem P., Rafnar T., Thorsteinsdottir U., Gudbjartsson DF., Masson G., Kong A., Stefansson K.
<jats:title>Key Points</jats:title> <jats:p>Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.</jats:p>