Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C.
Childs K., Davis C., Cannon M., Montague S., Filipe A., Tong L., Simmonds P., Smith D., Thomson EC., Dusheiko G., Agarwal K.
LAY SUMMARY: Direct acting antiviral medications are able to cure Hepatitis C in the majority of patients. The most common genotype of Hepatitis C in Europe and the United States is genotype 1a or 1b and most clinical trials focused on these genotypes. We report that in a group of African patients, most of them had unusual (non-1a/1b) genotype 1 subtypes, and that the cure rate in these unusual genotypes was lower than in genotypes 1a and 1b.