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To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO(2) and 93% N(2). Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested.

Original publication

DOI

10.1016/s0014-5793(02)02881-8

Type

Journal article

Journal

FEBS letters

Publication Date

07/2002

Volume

522

Pages

3 - 5

Addresses

Department of Organic Chemistry, University of Milan, CNR-ISTM, Via Venezian 21, Italy. diego.monti@unimi.it

Keywords

Erythrocytes, Animals, Humans, Plasmodium falciparum, Carbon Dioxide, Carbon Monoxide, Nitrogen, Chloroquine, Carboxyhemoglobin, Antimalarials, Molecular Structure, Oxidative Stress