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One hundred and fifty patients with severe falciparum malaria were administered sequential combination of dihydroartemisinin suppository followed by an oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/capsule) were given rectally once daily for 3 days with a total dose of 8-10 mg/kg. Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72 hr and 84 hr, respectively. The mean [SD] parasite clearance time and fever clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No death or major adverse drug effects occurred. The cure rate at 28 days of inpatient follow-up was 95% (113 of 119 patients). In severe malaria, dihydroartemisinin suppository followed by oral mefloquine is a suitable alternative treatment to parenteral drugs.

Type

Journal article

Journal

The American journal of tropical medicine and hygiene

Publication Date

11/2000

Volume

63

Pages

290 - 294

Addresses

Department of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Thailand.

Keywords

Humans, Malaria, Falciparum, Sesquiterpenes, Artemisinins, Mefloquine, Antimalarials, Treatment Outcome, Drug Therapy, Combination, Administration, Oral, Administration, Rectal, Drug Administration Schedule, Severity of Illness Index, Adolescent, Adult, Aged, Middle Aged, Child, Female, Male