Hash-Based Core Genome Multilocus Sequence Typing for Clostridium difficile
Eyre DW., Peto TEA., Crook DW., Walker AS., Wilcox MH.
Pathogen whole-genome sequencing has huge potential as a tool to better understand infection transmission. However, rapidly identifying closely related genomes among a background of thousands of other genomes is challenging. Here, we describe a refinement to core genome multilocus sequence typing (cgMLST) in which alleles at each gene are reproducibly converted to a unique hash, or short string of letters (hash-cgMLST).