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The aminoglycoside, aminosidine exhibited ED50S of between 1 and 5 microM against the amastigotes of Leishmania major and Leishmania tropica in mouse peritoneal macrophages whereas other strains causing New World cutaneous leishmaniasis such as Leishmania braziliensis were more refractory. Aminosidine was also active against all but one of the Leishmania donovani strains tested and when combined with sodium stibogluconate, the drug showed marked potentiation against the amastigotes of L. donovani in vitro and an additive effect in experimentally infected BALB/c mice.

Original publication

DOI

10.1093/jac/35.5.577

Type

Journal article

Journal

The Journal of antimicrobial chemotherapy

Publication Date

05/1995

Volume

35

Pages

577 - 584

Addresses

Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.

Keywords

Cells, Cultured, Macrophages, Peritoneal, Animals, Mice, Inbred Strains, Mice, Inbred BALB C, Mesocricetus, Mice, Leishmania, Leishmania donovani, Leishmaniasis, Visceral, Antimony Sodium Gluconate, Paromomycin, Drug Combinations, Microbial Sensitivity Tests, Drug Interactions, Female, Cricetinae, Male