Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A 20 d drug regimen of aminosidine (= paromomycin) at 12 mg/kg/d in combination with sodium stibogluconate at 20 mg/kg/d proved efficacious and well-tolerated in patients with visceral leishmaniasis in the State of Bihar, India. Eighteen of 22 evaluable patients achieved an ultimate cure. The remaining 4 patients, although not cleared of parasites, had their parasite grade reduced and also improved clinically. This confirms prior findings in Kenyan patients with kala-azar, and indicates that this regimen is a valid alternative to antimonial compounds alone in the State of Bihar, where cases of kala-azar not responding to antimonial drugs and intolerant of pentamidine are increasingly recorded.

Original publication

DOI

10.1016/0035-9203(92)90150-b

Type

Journal article

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date

11/1992

Volume

86

Pages

615 - 616

Addresses

Patna Medical College, Tripolia Social Service Hospital, India.

Keywords

Humans, Leishmaniasis, Visceral, Antimony Sodium Gluconate, Paromomycin, Drug Therapy, Combination, Pilot Projects, Adolescent, Adult, Aged, Middle Aged, Child, Child, Preschool, Infant, Female, Male