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The polymerisation of haemoglobin-derived ferri-protoporphyrin IX (Fe(III)PPIX) to haemozoin (malaria pigment) is a crucial process for intraerythrocytic plasmodia to prevent haem toxicity. It is also the target of in-use antimalarial drugs and newer compounds. This reaction and the inhibition thereof can be reproduced and studied in vitro.

Type

Journal article

Journal

Parassitologia

Publication Date

09/1999

Volume

41

Pages

205 - 208

Addresses

Istituto di Microbiologia, Università di Milano, Italy. donatella.taramelli@unimi.it

Keywords

Erythrocytes, Cells, Cultured, Animals, Humans, Plasmodium, Heme, Hemin, Hemeproteins, Antimalarials, Oxidation-Reduction, Electrochemistry