Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes
Abdullahi ST., Soyinka JO., Olagunju A., Bolarinwa RA., Olarewaju OJ., Bakare-Odunola MT., Winterberg M., Tarning J., Owen A., Khoo S.
There is an increased recognition of the need to identify and quantify the impact of genetic polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of the pharmacokinetic drug-drug interaction between nevirapine and artemether-lumefantrine in HIV-positive and HIV-negative adult Nigerian subjects.