Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia
Arezes J., Foy NJ., Mchugh K., Quinkert D., Benard S., Sawant A., Frost JN., Armitage AE., Pasricha S-R., Lim PJ., Tam MSK., LaVallie ER., Pittman D., Cunningham O., Lambert MA., Murphy JE., Draper SJ., Jasuja R., Drakesmith AH.
<jats:title>Key Points</jats:title> <jats:p>The N-terminus of ERFE binds BMP6 with nanomolar affinity and is sufficient to inhibit BMP signaling and suppress hepcidin in vivo Anti-N-terminal ERFE antibodies prevent Epo-induced hepcidin suppression and decrease iron accumulation and anemia in thalassemic mice</jats:p>