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The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been substantiated. Future genome-wide association studies will reveal more loci, each providing a piece to the genetic puzzle of autoimmune disease.

Original publication




Journal article


Current opinion in immunology

Publication Date





601 - 608


Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge, CB2 2XY, UK.


Animals, Mice, Inbred NOD, Humans, Mice, Diabetes Mellitus, Type 1, Genetic Predisposition to Disease, Insulin, Receptors, Interleukin, Antigens, Differentiation, Antigens, CD, Major Histocompatibility Complex, Interleukin-2 Receptor alpha Subunit, Protein Tyrosine Phosphatases, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Genetic Linkage, CTLA-4 Antigen