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The recent discovery of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining genes in animal models of the disease mark a fruitful period in the field of type 1 diabetes genetics. In addition, the similarities of the genetic and functional aspects across species have been substantiated. Future genome-wide association studies will reveal more loci, each providing a piece to the genetic puzzle of autoimmune disease.

Original publication

DOI

10.1016/j.coi.2005.09.013

Type

Journal article

Journal

Current opinion in immunology

Publication Date

12/2005

Volume

17

Pages

601 - 608

Addresses

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge, CB2 2XY, UK.

Keywords

Animals, Mice, Inbred NOD, Humans, Mice, Diabetes Mellitus, Type 1, Genetic Predisposition to Disease, Insulin, Receptors, Interleukin, Antigens, Differentiation, Antigens, CD, Major Histocompatibility Complex, Interleukin-2 Receptor alpha Subunit, Protein Tyrosine Phosphatases, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Genetic Linkage, CTLA-4 Antigen