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Tetrapeptide derived major histocompatability (MHC) II ligands have been developed that contain no unadulterated peptide bonds. These are the 'least peptidic' ligands for any MHC protein yet reported.

Original publication

DOI

10.1016/s0960-894x(99)00333-9

Type

Journal article

Journal

Bioorganic & medicinal chemistry letters

Publication Date

07/1999

Volume

9

Pages

2115 - 2118

Addresses

Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

Keywords

Lactams, Peptides, Histocompatibility Antigens Class II, Ligands, Inhibitory Concentration 50, Molecular Mimicry, Structure-Activity Relationship, Drug Design