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Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles.

Original publication

DOI

10.1128/JVI.02276-10

Type

Journal article

Journal

J Virol

Publication Date

04/2011

Volume

85

Pages

3367 - 3374

Keywords

Gene Expression, HIV-1, HLA-C Antigens, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Regulatory Elements, Transcriptional, Viral Load