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ABSTRACTPrevious studies have found an association between a single-nucleotide polymorphism 35 kb upstream of theHLA-Clocus (−35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across −35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the −35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles.

Original publication




Journal article


Journal of Virology


American Society for Microbiology

Publication Date





3367 - 3374