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The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.

Original publication




Journal article


Biochemical and biophysical research communications

Publication Date





104 - 107


Florey Institute for Host-Pathogen Interactions and the Department of Infection, Immunity and Cardiovascular Science (IICD), Sheffield University Medical School, Beech Hill Road, Sheffield, S. Yorkshire, S102RX, United Kingdom.


Humans, Aspartic Acid, Glycine, Severity of Illness Index, Amino Acid Substitution, Evolution, Molecular, Spike Glycoprotein, Coronavirus, Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines