Piperaquine Pharmacokinetics during Intermittent Preventive Treatment for Malaria in Pregnancy
Chotsiri P., Gutman JR., Ahmed R., Poespoprodjo JR., Syafruddin D., Khairallah C., Asih PBS., L’lanziva A., Otieno K., Kariuki S., Ouma P., Were V., Katana A., Price RN., Desai M., ter Kuile FO., Tarning J.
Dihydroartemisinin-piperaquine (DP) is a long-acting artemisinin combination treatment that provides effective chemoprevention and has been proposed as an alternative antimalarial drug for intermittent preventive therapy in pregnancy (IPTp). Several pharmacokinetic studies have shown that dose adjustment may not be needed for the treatment of malaria in pregnancy with DP.