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This multi-country prospective study investigated whether persistent systemic inflammation, measured by eight plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load<50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1,000 copies/mL) during long-term treatment. On-ART sCD14 and CRP concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations, and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.

Original publication

DOI

10.1093/infdis/jiaa787

Type

Journal article

Journal

The Journal of infectious diseases

Publication Date

29/12/2020

Addresses

Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.