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Mycobacterium marinum causes a systemic tuberculosis-like disease in fish and skin infections in humans that can spread to deeper structures, resulting in tenosynovitis, arthritis, and osteomyelitis. However, little information is available concerning (i) the intraspecific genetic diversity of M. marinum isolated from humans and animals; (ii) M. marinum genotype circulation in the different ecosystems, and (iii) the link between M. marinum genetic diversity and hosts (humans and fish). Here, we conducted a genetic study on 89 M. marinum isolates from humans (n = 68) and fish (n = 21) by using mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) typing. The results show that the M. marinum population is genetically structured not only according to the host but also according to the ecosystem as well as to tissue tropism in humans. This suggests the existence of different genetic pools in the function of the biological and ecological compartments. Moreover, the presence of only certain M. marinum genotypes in humans suggests a different zoonotic potential of the M. marinum genotypes. Considering that the infection is linked to aquarium activity, a significant genetic difference was also detected when the human tissue tropism of M. marinum was taken into consideration, with a higher genetic polymorphism in strains isolated from patients with cutaneous forms than from individuals with deeper-structure infection. It appears that only few genotypes can produce deeper infections in humans, suggesting that the immune system might play a filtering role.

Original publication

DOI

10.1128/jcm.01274-12

Type

Journal article

Journal

Journal of clinical microbiology

Publication Date

11/2012

Volume

50

Pages

3627 - 3634

Addresses

INSERM U1058 Infection by HIV and by agents with mucocutaneous tropism: from pathogenesis to prevention, Montpellier, France.

Keywords

Animals, Fishes, Humans, Mycobacterium marinum, Fish Diseases, DNA, Bacterial, Interspersed Repetitive Sequences, Genotype, Adolescent, Adult, Aged, Middle Aged, Child, Child, Preschool, Female, Male, Genetic Variation, Young Adult, Biota, Molecular Typing, Mycobacterium Infections, Nontuberculous