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The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.

Original publication

DOI

10.1002/cmdc.200800348

Type

Journal article

Journal

ChemMedChem

Publication Date

03/2009

Volume

4

Pages

329 - 334

Addresses

School of Chemistry, University of Southampton Highfield, Southampton SO17 1BJ, UK.

Keywords

Animals, Mice, Inbred C57BL, Mice, Galactosylceramides, Antigens, CD1, Cytokines, Lymphocyte Activation, Receptors, Natural Killer Cell, Natural Killer T-Cells