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The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I α2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study we show that CAR but not MHC class I allele HLA-A(*)0201 binds to Ad5 with high affinity when expressed on hamster cells. When both receptors are coexpressed on the cell surface of hamster cells, Ad5 fiber bind to a single high-affinity receptor, which is CAR.

Original publication

DOI

10.1128/jvi.73.5.4513-4517.1999

Type

Journal article

Journal

Journal of Virology

Publication Date

01/01/1999

Volume

73

Pages

4513 - 4517