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The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I alpha2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study we show that CAR but not MHC class I allele HLA-A*0201 binds to Ad5 with high affinity when expressed on hamster cells. When both receptors are coexpressed on the cell surface of hamster cells, Ad5 fiber bind to a single high-affinity receptor, which is CAR.

Original publication




Journal article


Journal of virology

Publication Date





4513 - 4517


Department of Respiratory Medicine & Allergy, The Guy's, King's College and St. Thomas' Hospitals School of Medicine, Thomas Guy House, Guy's Hospital, London SE1 9RT, United Kingdom.


CHO Cells, Animals, Humans, Adenoviruses, Human, Capsid, Receptors, Virus, Capsid Proteins, HLA-A2 Antigen, Gene Expression, Alleles, Cricetinae, Coxsackie and Adenovirus Receptor-Like Membrane Protein