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The expression of low molecular weight cytokeratins (normally expressed only in simple epithelia) in intraepithelial neoplasia of grade CIN III or greater in cervical biopsies has recently been described by Bobrow et al. Our study of 127 cases confirms this finding and in addition we compare the use of three monoclonal antibodies, namely NCL-5D3, CAM 5.2, and PKK1, in demonstrating the phenomenon. Both NCL-5D3 and CAM 5.2 give consistently negative results for non-neoplastic stratified squamous epithelium, as well as CIN I and CIN II lesions, whilst staining about 30 per cent of CIN III biopsies and most carcinomas. PKK1, on the other hand, stained 50 per cent of non-neoplastic epithelia and thus did not serve as a marker of severe dysplasia. The possible implications of these observations are discussed.

Original publication

DOI

10.1002/path.1711550111

Type

Journal article

Journal

The Journal of pathology

Publication Date

05/1988

Volume

155

Pages

71 - 75

Addresses

University Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.

Keywords

Humans, Carcinoma in Situ, Carcinoma, Squamous Cell, Antibodies, Monoclonal, Staining and Labeling, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Female, Keratins