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Prenatal array comparative genome hybridisation (aCGH) testing has by and large replaced routine karyotyping in many healthcare settings. While this will lead to more diagnoses, uncertain, unexpected or unhelpful findings are also likely to increase. This is the case for aCGH in any setting, but we discuss the particular challenges the prenatal setting generates and suggest areas that need further debate and discussion as well as some pragmatic ways forward.

Original publication




Journal article


Archives of disease in childhood. Fetal and neonatal edition

Publication Date





F338 - F341


Humans, Fetal Diseases, Chromosome Disorders, Prenatal Diagnosis, Incidental Findings, Parents, Choice Behavior, Pregnancy, Female, Comparative Genomic Hybridization