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Slices of rat hippocampus maintained in a medium containing Mn2+ and lowered Ca2+ concentration, which demonstrably blocked chemical synapses, generated spontaneous bursts of population spikes in all cell body layers after 30-60 min of incubation. Therefore, electrical interactions alone can synchronize neuronal activity in the hippocampus, and they are probably important during epileptiform events.

Original publication

DOI

10.1016/0006-8993(84)91443-4

Type

Journal article

Journal

Brain research

Publication Date

04/1984

Volume

298

Pages

382 - 385

Keywords

Hippocampus, Neurons, Synapses, Animals, Rats, Epilepsy, Calcium, Magnesium, Neurotransmitter Agents, Culture Techniques, Synaptic Transmission, Evoked Potentials